251-270 The Plague of Cyprian takes its name from Saint Cyprian, bishop of Carthage, who described symptoms that suggest measles or smallpox rather than bubonic plague. This epidemic killed the Roman emperor Claudius in 270, and is credited with encouraging mass conversions to Christianity. It has also been suggested as the time that Christians first began wearing black as the color of mourning. 

400 B.C. Hippocrates also recorded an outbreak of a cough followed by pneumonia and other symptoms, at Perinthus in northern Greece (now part of Turkey). Several possible identifications have been suggested, including influenza, whooping cough and diphtheria. 

410 B.C. The first recorded epidemic of mumps was described by Hippocrates, who was probably present on the Island of Thasos where the epidemic struck around 410. 

430 B.C. The Great Plague of Athens was described by Thucydides, who survived an attack himself. The symptoms described have been variously interpreted as smallpox, typhus, bubonic plague, or most recently, Ebola virus. The outbreak seriously impaired the Athenian army, and prolonged the Peloponnesian War. 

451 B.C. A severe outbreak of an unidentified disease struck Rome, and was recorded by the historians Livy and Dionysius of Halicarnasus. 

480 B.C. The Plague of Xerxes, probably an outbreak of dysentery, hit the Persian army, facilitating its defeat by the Greeks. The Greek historian Herodotus probably exaggerated its impact, but it is nonetheless significant as one of the first epidemics recorded in a lengthy written account. 

1st century A.D. The earliest unequivocal epidemic of bubonic plague in the Mediterranean occurred in Libya, Egypt and Syria. 

542 The Plague of Justinian was the first pandemic of bubonic plague, beginning in Egypt and Ethiopia and sweeping through the Mediterranean. About 300,000 people died in Constantinople alone during the first year. The Byzantine emperor Justinian was stricken, but recovered; however the disease crushed his ambitions to recover the full extent of the old Roman empire under his rule. Merchant ships carried the disease into the rest of the Mediterranean, and it flared up repeatedly in Europe for the next 50 years. 

569 A smallpox epidemic struck Arabia and forced the Ethiopian army to retreat, thus ending their rule there. This was known as the Elephant War epidemic, for the white elephant on which the Christian prince Abraha rode into Mecca before his defeat, and is described in the Koran. It was one of the earliest recorded epidemics of smallpox. 

590 A.D. Bubonic plague killed Pope Pelagius II, who was succeeded by the reformer Gregory the Great. 

680 A.D. Plague again struck Rome and Italy, and is credited with the origin of the cult of St. Sebastian, a third century martyr who was regarded as a protector against disease, because the epidemic abated after his bones were moved from Rome to the church of San Pietro in Vincoli in Pavia. 

700s-800s Japan suffered repeated epidemics of smallpox. The one in 735-736 killed several members of the ruling Fujiwara family, and led to a religious fervor that facilitated the spread of Buddhism. 

746-748 A.D. Constantinople was struck again by plague. 

1081 The army of the Holy Roman Emperor Henry IV was defeated by disease in his attempt to conquer Rome, probably typhoid fever and dysentery, and perhaps also malaria. 

1098 The First Crusade was delayed and made more difficult by disease, in particular by an epidemic probably of typhoid fever that struck in Syria in 1098 after the siege of Antioch. 

10th century Japan was struck again by smallpox epidemics, and also by measles. 

1148. An epidemic at Adalia on the coast of Anatolia wiped out soldiers and pilgrims of the Second Crusade and facilitated their defeat by the Turks. 

1167 The army of Frederick Barbarossa was nearly destroyed after his conquest of Rome in 1167 by an epidemic disease. Whether this was typhus, malaria, or something else has not been decided. 

1494-95 Syphilis first appeared in Europe, beginning among Spanish soldiers in Naples. Historians differ on whether it was brought back by explorers returning from America. The Italians called it the Spanish or French Disease, the French called it the Italian disease, the Russians called it the Polish disease, and the Arabs called it the disease of the Christians. Smallpox, which had existed previously in Europe, also got its modern name at this time, to distinguish it from syphilis which was also known as "the pox". 

1499 Plague struck London, causing thousands of deaths, the first of a number of outbreaks in that city. 

14th century. The Black Death, an outbreak of bubonic plague, was the most devastating single epidemic of all time, killing probably a third or more of the population of Europe and Asia. It originated in central Asia and had already killed an estimated 25 million people before it reached Constantinople in 1347. From there it was spread around the Mediterranean by merchant ships and by crusaders returning from the middle east. By 1350 it had spread throughout Europe, and at least another 25 million people had died. The social upheaval that ensued is generally regarded as the end of the Middle Ages. Outbreaks of bubonic plague continued sporadically in various European locations throughout the 15th and 16th centuries. 

1507 and 1518 Two epidemics of smallpox killed from a third to more than half of the native populations of Cuba, Haiti, and Puerto Rico. 

1507-1551 England was struck several times during this period by a mysterious disease characterized by profuse sweating. After the last outbreak in 1551, it disappeared permanently, and has never been identified unequivocally with a modern disease. 

1512 Syphilis struck Japan for the first time, and was attributed to Chinese traders coming to Nagasaki. 

1520 Smallpox followed by starvation killed millions of the native inhabitants of Mexico. Introduced at Veracruz with the arrival of Panfilo de Narvaez on April 23, 1520, it rapidly spread inland, and was credited with the victory of Cortes over the Aztec empire at Tenochtitlan (present-day Mexico City) in 1521. From Mexico it spread south into central and south America, exterminating huge numbers of natives in those areas as well. 

1525-27 Smallpox in Peru killed the Inca ruler, Huayna Capac, and some 200,000 others, and destroyed the Inca Empire. 

1528 Typhus attacked French troops besieging Naples, killing well over half the army. The remaining soldiers retreated and were then destroyed by forces of the Holy Roman Empire. The troops of Charles V later suffered their own defeat to typhus at the French city of Metz in 1552, however. 

1555 Smallpox struck Brazil for the first time, killing vast numbers of natives. 

1560s Bubonic plague struck London again in 1563, and was probably its worst outbreak ever, killing an estimated quarter to a third of the population. Subsequent outbreaks occurred in 1578,

1576 Mexico's first epidemic of typhus killed many natives. This was another of the lethal diseases introduced by Europeans. 

1576 Paris and several other European cities suffered from diphtheria. This epidemic marks the first accurate description of this disease, by the physician Guillaume de Baillou. Two years later he described whooping cough in its first confirmed outbreak, although the disease probably had existed prior to this time. 

1590-1610 Plague swept many European cities again. 

1591 Smallpox struck the Philippines for the first time, arriving on a Spanish ship from Mexico and spreading through the country with high mortality rates. 

1592-96 One of the earliest outbreaks of measles among native Americans in North America struck the Seneca Indians in central New York state, and caused hundreds or maybe thousands of deaths. 

1593, 1603, 1625, 1636, and 1665, each time killing thousands. In terms of proportion of the total population destroyed, the 1563 and 1665 epidemics were the worst. 

1617-1619 A smallpox outbreak killed 90% of the Massachusetts Bay Indians, probably introduced from fishing boats that visited the coast before there was a permanent English settlement there. The few remaining natives were weakened, and were unable to resist the landing of the Mayflower settlers at Plymouth in 1620. 

1618 Italy was swept by outbreaks of diphtheria. 

1618-48 The period of the Thirty Years War in Germany was marked by repeated epidemics, including typhus, plague and dysentery that spread to other European countries. 

1625-40 Bubonic plague spread through France. Probably the worst single outbreak was in Lyon in 1628. 

1628-1631 New England Small Pox 

1633 Smallpox again struck the Indians in Massachusetts, probably brought on arriving ships of settlers. At least 15 children died on incoming ships, as well as about 20 colonists already resident. 

1634 Smallpox in Connecticut, a catastrophic epidemic that was introduced by Dutch traders and killed 95% of the Indians along the Connecticut River, and spread north into Canada. The English settlers were mostly immune, having had the disease as children themselves, but attributed their escape, and the Indians' death, to God's will. The elimination of the natives in the Connecticut valley opened up that area to settlement. 

1638 New England Small Pox & Spotted Fever 

1647 Yellow fever killed more than 5,000 people in Barbados, and spread from there to Mexico, Cuba, and elsewhere. A second outbreak in 1691 killed many of the British settlers in Barbados, who had arrived since the earlier outbreak, whereas older natives were by this time immune. 

1648-49 Another smallpox outbreak spread to many towns in the Massachusetts colony. By this time there had been many children born in the colony who were susceptible. A simultaneous epidemic of whooping cough added to the severity of the epidemic, and to the overall death toll. 

165-80 The Antonine Plague, or Plague of Galen, was probably smallpox or measles, or both, and was brought back to the Roman Empire by troops returning from the Middle East. The Roman emperors Lucius Verus and Marcus Aurelius Antoninus both died from it, in 169 and 180 respectively. 

1657-1658 Boston Measles 

1659 Massachusetts Bay Colony Throat Distemper 

1662 Smallpox killed more than a thousand Iroquois in central New York state. 

1665 The Great Plague of London killed at least 20 percent of the city's population, perhaps as many as 100,000 people. 
1666 A smallpox outbreak struck Boston, but was relatively mild, and only about 40 people died. 

1668 Probably the earliest recorded epidemic of yellow fever non-tropical America, striking New York in late summer and early fall of 1668, and described as an "autumnal bilious fever in infectious form". The contemporary descriptions leave some possibility open that it could have been some other disease, but yellow fever seems the most likely. 

1677-78 Charlestown & Boston Small Pox Another smallpox epidemic in Boston was much worse than the 1666 epidemic, and killed several of the town leaders. 

1679 Plague spread from the Ottoman Empire into Austria, killing thousands of people especially in Vienna. 

1679-1680 Virginia Small Pox 1687 Boston Measles 

1687 - Boston -- Measles 

1689-1690 New England Small Pox 

1690 New York Yellow Fever 

1693 Boston, MA Yellow Fever 

1696 Jamestown, VA Small Pox 

1699 Charleston & Philadelphia Charleston SC had an epidemic, the first there to be positively identified as yellow fever; probably about 160-190 died. 

1699 South Carolina Small Pox 

1702 Yellow fever struck New York, killing more than 500 people over a three-month period, which was probably about 10% of the population at the time. 

1702-1703 Smallpox hit Boston again. This time about 300 died, but a simultaneous outbreak of scarlet fever makes it hard to assess who died from what. 

1706 Charleston SC was struck with yellow fever again. About 5% of the population died. 

1711-1712 South Carolina Small Pox 

1713 Boston Measles 

1715-1725 Most of the Colonies Small Pox 

1720 Another outbreak of plague in France, centered on Marseilles and killing probably a third to half the population there. 

1721-22 Smallpox struck Boston again, with about 6000 people affected in a total population of 11,000, of whom 844 died. This epidemic prompted the first use of inoculation against smallpox in the New World. 

1723-1730 Boston, New York, Philadelphia Small Pox 

1728,1732 Charleston SC was hit by yellow fever twice in a four year period. The cause (mosquitoes) was not understood, and treatment wasn't very effective.

1729 Boston Measles 

1732 Charleston & New York Yellow Fever 

1732-3 Worldwide Influenza 

1734 Virginia Yellow Fever 

1735-1740 New England Small Pox, Scarlet Fever & Diphtheria 

1735-40 Epidemics of diphtheria and scarlet fever spread through various parts of New England. Both diseases were referred to as "throat distemper" and weren't distinguished. Hundreds of people died, most of them children. 

1738 South Carolina Smallpox 

1739-40 Boston Measles 

1741 Virginia Yellow Fever 

1743-1745 Yellow fever struck New York again. A correlation with the dockyard areas was noticed, but mosquitoes were still not recognized as the vector. 

1747 CT,NY,PA,SC Measles 

1752 Boston, MA Small Pox 

1759 North America [areas inhabited by white people] Measles 

1760-1761 Connecticut, Rhode Island, Massachussetts, Charleston Small Pox 

1761 North America and West Indies Influenza 

1762 Philadelphia Yellow Fever 

1763 Philadelphia Throat Distemper 

1763-64 Smallpox hit Boston once again, with about 170 deaths. This epidemic was less serious than previous ones, probably because of inoculation. 

1764 Boston, MA Small Pox 

1769 New York Throat Distemper 

1772 - North America Measles 

1772-1774 New England Small Pox 

1775 - North America [especially hard in Northeast] epidemic Unknown

1775-6 Worldwide [one of the worst epidemics] Influenza 
.
1776 Boston, MA Small Pox 

1778 Boston, MA Small Pox 

1783 Dover, DE ["extremely fatal"] Bilious Disorder 

1784 - New Bern, NC (Craven Co) -- Yellow Fever 

1788 Philadelphia and New York Measles 

1789 A widespread epidemic of influenza hit New England, New York and Nova Scotia in fall

1789 Most deaths appear to have been from secondary pneumonia. 

1792 Boston, MA Small Pox 

1792-99 Yellow fever ravaged cities all along the east coast, including Charleston, Philadelphia, New Haven, New York, and Baltimore. The outbreak in Philadelphia in the summer of 1793 was the most severe, and most memorable. The disease was probably introduced from ships carrying French refugees who were fleeing turmoil in Santo Domingo, and then spread by mosquitoes that bred in stagnant water that in years with more rain had been waterways and canals. Ten percent of the population in that city died, about 5,000 people altogether. The new city of Washington DC was under construction at the time, and Philadelphia was the interim capital. Most of the government officials fled the city, including George Washington and the members of his cabinet. Various treatments were tried, none of them very effective, and controversy raged over the best way to prevent and treat the disease. Cold weather finally brought an end to the outbreak, in late October. 

1793 Harrisburg, PA [many unexplained deaths] Unknown 

1793 Middletown, PA [many mysterious deaths] Unknown 

1793 Philadelphia [one of the worst epidemics] Yellow Fever 

1793 VA [killed 500 in 5 counties in 4 weeks] Influenza 

1793 Vermont [a "putrid" fever] and Influenza 

1794 Philadelphia, PA Yellow Fever 

1796-7 Philadelphia, PA Yellow Fever 

1798 - New Bern, NC (Craven Co) -- Yellow Fever 

1798 Philadelphia, PA [one of the worst] Yellow Fever 

1802 Smallpox killed about two thirds of the Omaha Indians in what is now northeast Nebraska. 

1803 New York Yellow Fever 

1805, and spread throughout central Europe with Napoleon's army, affecting both soldiers and civilians. 

1805-07 Typhus outbreaks occurred during the occupation of Vienna by the French army in

1812-1813 Napoleon's army was attacked again by typhus and dysentery during his invasion of Russia, both on the march eastward and again on the return, where disease was exacerbated by severe cold and starvation. It is estimated that only about 30,000 survived of the nearly 600,000 troops that began the campaign. 

1817-1823 The first great cholera pandemic of the 19th century swept Asia, probably originating near Calcutta and spreading from there throughout southeast Asia, Japan and China. Although it spread as far as southern Russia and the middle east, an exceptionally cold winter in 1823-24 kept it from reaching western Europe. 

1820-3 Nationwide [starts-Schuylkill River and spreads] "Fever" 

1826-28 Dengue fever spread from Savannah, Georgia, to other cities along the southeastern coast, and through the Caribbean. 

1826-37 The second cholera pandemic of the 19th century, and the most devastating one, began in Bengal and spread through India in 1826. It reached Afghanistan in 1827, and spread further into central Asia and the middle east. By late 1830 it had reached Moscow, and from there spread westward into Europe in 1831. It reached England on a ship from Hamburg in October

1829 by a ship reaching Oregon after coming from Chile, carrying infected mosquitoes in water tanks onboard ship. The Columbia River was flooded at the time, creating stagnant water in which the mosquitoes could breed. 

1829-33 In the Pacific northwest, malaria killed an estimated 150,000 native Americans. Other diseases may have contributed to the death toll, but contemporary writing describes symptoms that closely correspond to those of malaria. The disease was probably introduced in February

1830-31 An influenza epidemic began in Asia, probably China, late in 1829, and spread from there to the Philippines in September 1830, to Indonesia in January 1831, through the Malay peninsula and into Asia in 1832. The disease also broke out in Moscow and St. Petersburg in the winter of 1830-31 and spread westward overland through the summer of 1831. By November it had reached the U.S., and continued to spread there in 1832. Another outbreak of influenza spread through Asia and Europe during 1836-37 but except for a single Canadian focus did not reach North America. 

1831 and spread throughout the British Isles. It reached New York in 1832, and spread from there throughout most of the U.S. 

1831-2 Nationwide [brought by English emigrants] Asiatic Cholera 

1832 New York City and other major cities Cholera 

1833 Columbus, OH Cholera 

1834 New York City Cholera 

1837 Philadelphia Typhus 

1837 Smallpox started with a Sioux tribe in Missouri in June 1837, then spread to Blackfoot and other tribes in Montana and Saskatchewan. The last previous outbreak among the Blackfoot had been in 1781, so by 1837 most of the population was susceptible. 

1841 Nationwide [especially severe in the south] Yellow Fever 

1847 Hundreds of Cayuse Indians in the Pacific northwest were killed by measles. This tribe had never been exposed to measles previously, and missionaries were blamed for introducing it. One missionary near present-day Walla Walla tried to provide them with food and medicine, but the Indians thought he was making it worse, and killed him, his wife and twelve others at the mission, and took a number of others hostage. Several years of conflict followed. 

1847 New Orleans Yellow Fever 

1847-8 Worldwide Influenza 

1848-9 North America Cholera 

1849 New York Cholera 

1849 The third major worldwide pandemic of cholera, again starting in Bengal, reached Europe and the U.S. in 1848-49. The English physician John Snow demonstrated in 1854 that it was spread by contaminated water. 

1850 Nationwide Yellow Fever 

1850-1 North America Influenza 

1850-51 An extensive epidemic of dengue fever began in Charleston SC, then spread to Savannah, Augusta, New Orleans, Mobile, Galveston, and other southern coastal cities. 

1851 Coles Co., Illinois, The Great Plains, and Missouri Cholera 

1852 Nationwide [New Orleans-8,000 die in summer] Yellow Fever 

1853 Smallpox was introduced to Hawaii by a ship arriving from San Francisco. At least 2500 people died, possibly as many as 5,000. 

1855 Nationwide [many parts] Yellow Fever 

1857-9 Worldwide [one of the greatest epidemics] Influenza 

1860-1 Pennsylvania Smallpox 

1861-65 The U.S. Civil War brought epidemics of dysentery, typhoid fever, hepatitis, malaria, smallpox, measles, and venereal diseases. More than three times as many soldiers died of infectious disease than died of battle wounds. 

1863-66 The fourth cholera pandemic of the 19th century began in India in 1863, spread first to the middle east, and then into the Mediterranean. It arrived in New York on a ship coming from France in October 1865, and spread rapidly. Public health reform kept the death toll lower than in previous epidemics, but there were tens of thousands of deaths nonetheless. Another wave swept through the south and midwest in 1873, hitting particularly hard in the Mississippi and Ohio valleys. 

1865-73 - Baltimore, Memphis, Washington DC -- Cholera [A series of recurring epidemics of: Typhus, Typhoid, Scarlet Fever, Yellow Fever] 

1865-73 - Philadelphia, New York, Boston, New Orleans -- Smallpox 

1865-73 Philadelphia, NY, Boston, New Orleans Smallpox Baltimore, Memphis, Washington DC Cholera A series of recurring epidemics of: Typhus, Typhoid, Scarlet Fever, Yellow Fever 

1868-75 Smallpox outbreaks hit New York, Philadelphia and other cities, and it was discovered that many children had not been vaccinated. The New York City Board of Health recommended that all residents be vaccinated in 1870, but there was widespread public resistance, since the vaccine itself was not without risk, and people perceived the campaign as creating a panic situation and allowing doctors to profit from it. 

1873-5 - North America and Europe Influenza 

1875-76 A particularly bad epidemic of scarlet fever swept Australia, with high mortality rates. 

1878 New Orleans [last great epidemic] Yellow Fever 

1878-79 Yellow fever again swept through New Orleans, Memphis, and the Mississippi and Ohio River valleys. 

1881-1896 A fifth cholera pandemic was notable for the discovery of its cause, by the German physician Robert Koch. Like its predecessors, this epidemic began in India, and spread both east and west from there. By this time improvements in sanitation kept it from affecting many European cities, and improved diagnosis and quarantine measures kept it out of the U.S. A sixth pandemic began in 1899, and continued to spread through Asia over the next ten years. The U.S. was not affected, nor were most western European cities. 

1885 Plymouth, PA Typhoid 

1886 Jacksonville, FL Yellow Fever 

1887 Paralytic polio was first described in an epidemic in Sweden. 

1889-90 A worldwide epidemic of influenza, the most devastating to that time, began in central Asia in the summer of 1889, spread north into Russia, east to China and west to Europe. By December it had struck the major U.S. cities, and continued to spread through North America the following year. Parts of Africa and the middle east were infected early in 1890; and India, southeast Asia, Australia and New Zealand were reached between February and May. Completing the circle, eastern China had the last major outbreak of this pandemic, in September and October of 1890. 

1890s The third plague pandemic began in China in the 1850s and spread slowly until it reached the seaports in the 1880s, then spread more rapidly around the world, striking particularly hard in India, Egypt and north Africa, and South America. The continental U.S. was largely spared, but Hawaii suffered a severe outbreak in 1899, and San Francisco was affected in 1900-1904, and again in 1907-1909. The second outbreak there was exacerbated by unsanitary conditions following the earthquake of 1906. Sporadic outbreaks continued worldwide for years, and officially this pandemic was not considered over until 1959. 

1893-94 The first large recorded outbreak of polio in the U.S. began in Boston, and spread into New England, particularly Vermont. Of 132 cases documented in Vermont, there were 18 deaths and 30 victims left with permanent paralysis. 

1901-03 Smallpox had its last major outbreak in the urban northeast U.S., beginning in New York and spreading through other major cities. 

1907-1916 Polio turned into a major problem in the U.S., with about a thousand cases in New York in 1907, and another outbreak in 1911. The disease was recognized as contagious, but there was no understanding yet of exactly how it was spread. The first widespread outbreak, seriously affecting 26 states, occurred in 1916. About 7,000 deaths were recorded. 

1917-1919 The most lethal influenza pandemic ever killed half a million people worldwide. Its spread was facilitated by troop movements in the closing months of World War I. Mortality rates were unusually high for flu, especially among young, otherwise healthy adults. Deaths occurred both from the flu itself and from secondary pneumonia. 

1918 - Worldwide [high point year] -- Influenza More people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps  Finally, these specific instances of Cholera were mentioned:

1918 Worldwide[high point yr] more people were hospitalized in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps Influenza

1931 Another outbreak of polio swept the U.S. during the summer of 1931, killing more than 4,000 people, about 12 percent of the reported cases. 

1942-53 Polio continued to ravage the U.S., peaking in 1952 with about 60,000 cases. Introduction of the Salk vaccine in 1955 brought an end to the epidemic. 

1957-58 The "Asian flu" started in southwest China in February 1957, possibly having originated in 1956 in Vladivostok. Globally it affected 10-35% of the population but overall mortality was much lower than in the 1918 epidemic, about 0.25%. The flu spread to Hong Kong and Singapore in April 1957, Japan in May, elsewhere in Pacific in June, the middle east and Africa in July, Europe in August-October, and the U.S. in October of 1957.